Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334422 | 0.77 | HIF1A (0.39) | CES1ALDH1A1BCHECES2GAA | |
| SCHEMBL2865639 | 0.77 | KMT2A (0.42) | ALDH1A1NR1H3NR1H2POLBMEN1 | |
| SCHEMBL8443315 | 0.74 | ALDH1A1 (0.67) | CES1ALDH1A1BCHECES2GAA | |
| SCHEMBL25433322 | 0.74 | HIPK2 (0.44) | CES1ALDH1A1BCHECES2GAA | |
| SCHEMBL7078045 | 0.73 | PDE6D (0.52) | ALDH1A1GAAPOLBMEN1KMT2A | |
| SCHEMBL8098957 | 0.73 | KDR (0.39) | CES1ALDH1A1BCHECES2GAA | |
| SCHEMBL1990739 | 0.72 | TDP2 (0.31) | — | |
| SCHEMBL16862997 | 0.67 | POLB (0.50) | CES1ALDH1A1NR1H3NR1H2POLB | |
| SCHEMBL28358758 | 0.67 | ALDH1A1 (0.50) | CES1ALDH1A1BCHECES2GAA | |
| SCHEMBL31107472 | 0.66 | TTR (0.64) | CES1ALDH1A1NR1H3NR1H2TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641435-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2006-04-05 | — | — | EP | claimed |
| US-20050031669-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED (US) | 2005-02-10 | — | — | US | claimed |
| WO-2004112748-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2004-12-29 | — | — | WO | claimed |
| US-20040253293-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED | 2004-12-16 | — | — | US | claimed |
| WO-2012025726-A1 | Novel Hybrid Compounds | UNIVERSITY OF GREENWICH (GB) | 2012-03-01 | — | — | WO | disclosed |
| EP-1641435-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2006-04-05 | — | — | EP | disclosed |
| US-20050031669-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004112748-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040253293-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED | 2004-12-16 | — | — | US | disclosed |