Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431592 | 0.88 | TDP1 (0.42) | TDP1IDO1ALDH1A1GLATP53 | |
| SCHEMBL7255966 | 0.74 | IDO1 (0.56) | IDO1PRMT5WDR77 | |
| SCHEMBL10411981 | 0.73 | TDP1 (0.49) | TDP1ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL5925483 | 0.72 | TDP1 (0.52) | TDP1ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL7267976 | 0.72 | TDP1 (0.44) | TDP1ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL11289312 | 0.72 | ACHE (0.44) | TDP1ALDH1A1GLATP53CYP3A4 | |
| SCHEMBL72445 | 0.71 | IDO1 (0.52) | IDO1PRMT5WDR77 | |
| SCHEMBL22051969 | 0.71 | IDO1 (0.52) | IDO1PRMT5WDR77 | |
| SCHEMBL13049209 | 0.71 | IDO1 (0.52) | IDO1PRMT5WDR77 | |
| SCHEMBL19839314 | 0.70 | IDO1 (0.53) | TDP1IDO1ALDH1A1GLATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030064994-A1 | Substituted alkyl piperazine derivatives | CV THERAPEUTICS, INC. | 2003-04-03 | — | — | US | disclosed |
| EP-1259493-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6451798-B2 | PROTECTING SKELETAL MUSCLES AGAINST TRAUMA DAMAGE AND SUBSEQUENT TO DISEASE; TREATING SHOCK AND CARDIOVASCULAR DISEASES; PRESERVING DONOR TISSUE AND ORGANS USED IN TRANSPLANTS | CV THERAPEUTICS, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20010047001-A1 | Substituted alkyl piperazine derivatives | CV THERAPEUTICS, INC. | 2001-11-29 | — | — | US | disclosed |
| WO-2001062744-A2 | SUBSTITUTED PIPERAZINE COMPOUNDS | CV THERAPEUTICS, INC. (US) | 2001-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047001-A1 | Substituted alkyl piperazine derivatives | ATP2A1, CPT1B, TNNC1 | TDP1 3188/4885IDO1 3127/4885ALDH1A1 79/4885 |
| US-20030064994-A1 | Substituted alkyl piperazine derivatives | ATP2A1, CPT1B, TNNC1 | TDP1 3188/4885IDO1 3127/4885ALDH1A1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.