Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007270 | 0.78 | OPRM1 (0.47) | ALDH1A1HTR2BCHRM2CHRM4CHRM5 | |
| SCHEMBL1768990 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HTR2BCHRM2CHRM4CHRM5 | |
| SCHEMBL1768861 | 0.76 | CTSL (0.55) | OPRM1MEN1KMT2A | |
| SCHEMBL31312479 | 0.75 | GPR88 (0.38) | ACHEHTR2BCHRM2CHRM4CHRM5 | |
| SCHEMBL5802065 | 0.75 | OPRM1 (0.49) | ALDH1A1HTR2BCHRM2CHRM4CHRM5 | |
| SCHEMBL1769167 | 0.75 | OPRM1 (0.42) | ALDH1A1ACHEHTR2BCHRM2CHRM4 | |
| SCHEMBL21640853 | 0.75 | OPRK1 (0.45) | TDP1ACHEHTR2BCHRM2CHRM4 | |
| SCHEMBL1769117 | 0.75 | ALDH1A1 (0.40) | ALDH1A1HTR2BCHRM2CHRM4CHRM5 | |
| SCHEMBL12321049 | 0.74 | ACHE (0.45) | ALDH1A1ACHEHTR2BCHRM2CHRM4 | |
| SCHEMBL15641647 | 0.74 | NPC1 (0.52) | TDP1ALDH1A1ACHEHTR2BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0439796-B1 | Indolylpropanols, process for their preparation, and their use and preparations containing them | BEIERSDORF LILLY GMBH (DE) | 1996-01-24 | — | — | EP | disclosed |
| EP-0297380-B1 | Indolyl propanols, process for their preparation, their uses and preparation containing them | BEIERSDORF LILLY GMBH (DE) | 1994-10-05 | — | — | EP | disclosed |
| US-5145849-A | Inotropic and antiarrythmia agents; sodium channel inhibitors | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1992-09-08 | — | — | US | disclosed |
| EP-0439796-A2 | Indolylpropanols, process for their preparation, and their use and preparations containing them | Beiersdorf-Lilly GmbH (DE) | 1991-08-07 | — | — | EP | disclosed |
| US-4935414-A | New indolylpropanols, processes for their preparation and their use, and preparations containing the compounds | BEIERSDORF AG (DE) | 1990-06-19 | — | — | US | disclosed |
| EP-0297380-A2 | Indolyl propanols, process for their preparation, their uses and preparation containing them | Beiersdorf-Lilly GmbH (DE) | 1989-01-04 | — | — | EP | disclosed |