Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.60 |
| ▸ | MMP1 | P03956 | 7/20 | 0.60 |
| ▸ | MMP3 | P08254 | 7/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.60 |
| ▸ | MMP8 | P22894 | 6/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077710 | 0.87 | MMP2 (0.70) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7075141 | 0.84 | MMP2 (0.80) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL1858307 | 0.81 | MTNR1A (0.53) | GRIK1KMT2ARAB9A | |
| SCHEMBL27517321 | 0.79 | MMP2 (0.81) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7073281 | 0.79 | MMP2 (0.58) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7075404 | 0.78 | MMP2 (0.67) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7431052 | 0.78 | MMP2 (0.58) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7534733 | 0.78 | MMP2 (0.58) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7078224 | 0.77 | MMP2 (0.77) | MMP2MMP1MMP3MMP9MMP8 | |
| SCHEMBL7075406 | 0.77 | MMP2 (0.77) | MMP2MMP1MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030207889-A1 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity | OWEN DAVID ALAN (GB) | 2003-11-06 | — | — | US | disclosed |
| US-6566384-B1 | For therapy of cancer, inflammation and inflammatory diseases, tissue degeneration, periodontal disease, ophthalmological disease, dermatological disorders, fever, cardiovascular effects, haemorrhage, coagulation and acute phase response | DARWIN DISCOVERY LTD. (GB) | 2003-05-20 | — | — | US | disclosed |
| US-6118001-A | ANTICANCER AGENT; ANTIARTHRITIC AGENT | DARWIN DISCOVERY, LTD. (GB) | 2000-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207889-A1 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity | MMP13, MMP2, MMP9 | MMP2 2/4885MMP1 16/4885MMP3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.