SCHEMBL7078746

SCHEMBL7078746

Oc1cc(Cl)c(OCCCCCOc2ccc(C(F)(F)F)cn2)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 2/20 0.46
KMT2A Q03164 2/20 0.45
L3MBTL1 Q9Y468 2/20 0.41
MAPK1 P28482 1/20 0.39
RXRA P19793 3/20 0.39
GRIN1 Q05586 3/20 0.39
GRIN2B Q13224 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
TSHR P16473 1/20 0.39
RAB9A P51151 1/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
HPGD P15428 1/20 0.38
THRB P10828 1/20 0.37
GABRA5 P31644 1/20 0.37
MGLL Q99685 1/20 0.36
LIPE Q05469 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7076311 1.00 MRGPRX4 (0.46) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7073751 0.99 MRGPRX4 (0.47) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7071031 0.96 KMT2A (0.46) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7073314 0.95 KMT2A (0.47) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7072961 0.90 MRGPRX4 (0.43) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL4624147 0.88 KMT2A (0.41) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7073758 0.88 KMT2A (0.41) MRGPRX4KMT2AL3MBTL1MAPK1SMN1; SMN2
SCHEMBL7078903 0.86 L3MBTL1 (0.48) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL4143262 0.84 L3MBTL1 (0.46) MRGPRX4KMT2AL3MBTL1MAPK1RXRA
SCHEMBL7071231 0.83 L3MBTL1 (0.48) MRGPRX4KMT2AL3MBTL1MAPK1RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6589914-B2 The dihalopropene compounds of the general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks. SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-07-08 US disclosed
US-20030073847-A1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED 2003-04-17 US disclosed
US-6376428-B1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-04-23 US disclosed
US-6268313-B1 CONTROLLING INSECTS, MITES, TICKS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-07-31 US disclosed
US-6071861-A FOR THE CONTROL OF NOXIOUS INSECTS, MITES AND TICKS SUMITOMO CHEMICAL COMPANY, INC. (JP) 2000-06-06 US disclosed
EP-0785923-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-04-05 EP disclosed
US-5922880-A CONTROLLING INSECTS, MITES AND TICKS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-07-13 US disclosed
EP-0785923-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1997-07-30 EP disclosed
WO-1996011909-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073847-A1 Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production DDT, DDC, AADAC MRGPRX4 1668/4885KMT2A 2833/4885L3MBTL1 1034/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.