Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 9/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790955 | 0.86 | HTR1B (0.54) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL7084585 | 0.82 | HTR1B (0.52) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL3794323 | 0.82 | HTR1B (0.55) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL13309274 | 0.79 | HTR1B (0.52) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL502401 | 0.79 | HTR1B (0.52) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL8723087 | 0.79 | HTR1A (0.55) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL9057087 | 0.78 | HTR1A (0.49) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL15951727 | 0.76 | HTR1A (0.51) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL9057962 | 0.76 | RHEB (0.49) | HTR1BHTR1AADRB2ADRB1CYP1A2 | |
| SCHEMBL13003014 | 0.76 | HTR1A (0.50) | HTR1BHTR1AADRB2ADRB1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349848-A2 | ARYLOXY PIPERIDINYL INDOLES FOR TREATING DEPRESSION | Wyeth (US) | 2003-10-08 | — | — | EP | disclosed |
| US-6489342-B2 | 5-FLUORO-3-(1-(2-(1H-INDOL-4-YLOXY)ETHYL)-PIPERIDIN-4-YLMETHYL) -1H-INDOLE, FOR EXAMPLE; ACT AT THE 5-HT1A AUTORECEPTORS AND CONCOMITANTLY WITH THE 5-HT TRANSPORTER | WYETH | 2002-12-03 | — | — | US | disclosed |
| US-20020099078-A1 | Aryloxy piperidinyl indoles for treating depression | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-07-25 | — | — | US | disclosed |
| WO-2002040465-A2 | ARYLOXY PIPERIDINYL INDOLES FOR TREATING DEPRESSION | WYETH (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099078-A1 | Aryloxy piperidinyl indoles for treating depression | TPH2, TPH1, HTR2C | HTR1B 8/4885HTR1A 4/4885ADRB2 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.