Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794323 | 0.86 | HTR1B (0.55) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL7084585 | 0.83 | HTR1B (0.52) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL8723087 | 0.83 | HTR1A (0.55) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL3790955 | 0.80 | HTR1B (0.54) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL15951727 | 0.80 | HTR1A (0.51) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL13309274 | 0.79 | HTR1B (0.52) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL7079421 | 0.79 | HTR1B (0.52) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL15311730 | 0.79 | TRPA1 (0.51) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL11551128 | 0.78 | HTR1A (0.48) | HTR1BHTR1AADRB1CYP1A2CYP3A4 | |
| SCHEMBL5851174 | 0.78 | KMT2A (0.51) | HTR1BHTR1AADRB1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119219598-A | Cyclohexane derivative and medical application thereof | 上海京新生物医药有限公司 | 2024-12-31 | — | — | CN | disclosed |
| US-20120088792-A1 | Pyridin-2-YL Methylamine Derivatives for Treating Opiate Dependence | PIERRE FABRE MEDICAMENT (FR) | 2012-04-12 | — | — | US | disclosed |
| US-8106074-B2 | Pyridin-2-yl-methylamine derivatives for treating opiate dependence | PIERRE FABRE MEDICAMENT (FR) | 2012-01-31 | — | — | US | disclosed |
| US-20100099709-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES FOR TREATING OPIATE DEPENDENCE | PIERRE FABRE MEDICAMENT (FR) | 2010-04-22 | — | — | US | disclosed |
| EP-1406627-B1 | PYRIDIN-2-YL-METHLYAMINE DERIVATIVES FOR TREATING OPIOID DEPENDENCE | PF MEDICAMENT (FR) | 2006-11-08 | — | — | EP | disclosed |
| US-20050065348-A1 | Pyridin-2-yl-methylamine derivatives for treating opioid dependence | PIERRE FABRE MEDICAMENT (FR) | 2005-03-24 | — | — | US | disclosed |
| EP-1406627-A1 | PYRIDIN-2-YL-METHLYAMINE DERIVATIVES FOR TREATING OPIOID DEPENDENCE | PIERRE FABRE MEDICAMENT (FR) | 2004-04-14 | — | — | EP | disclosed |
| EP-1135360-B1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PF MEDICAMENT (FR) | 2004-03-31 | — | — | EP | disclosed |
| EP-0923548-B1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS | WYETH CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2003006020-A1 | PYRIDIN-2-YL-METHLYAMINE DERIVATIVES FOR TREATING OPIOID DEPENDENCE | PIERRE FABRE MEDICAMENT (FR) | 2003-01-23 | — | — | WO | disclosed |
| EP-1187824-A2 | NOVEL (2-SUBSTITUTED-5 - 3-THIENYL) -BENZYL]- 2- ( 2-ISOPROPOXY-5-FLUORO] -PHENOXY) -ETHYL] -AMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 2002-03-20 | — | — | EP | disclosed |
| US-6350913-B1 | AROMATIC AMINE COMPOUNDS | PIERRE FABRE MEDICAMENT (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1135360-A1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000058282-A2 | NOVEL [(2-SUBSTITUTED-5 -[3-THIENYL) -BENZYL]-[2- ([2-ISOPROPOXY-5-FLUORO] -PHENOXY) -ETHYL] -AMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | PIERRE FABRE MEDICAMENT (FR) | 2000-10-05 | — | — | WO | disclosed |
| WO-2000032557-A1 | NOVEL 3-ALKOXYBENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICINES FOR TREATING SCHIZOPHRENIA | PIERRE FABRE MEDICAMENT (FR) | 2000-06-08 | — | — | WO | disclosed |
| US-5958965-A | TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0923548-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008817-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |
| US-3906000-A | Tricyclicazaindole derivatives | PFIZER | 1975-09-16 | — | — | US | disclosed |
| US-3898245-A | Tricyclicazaindole derivatives | PFIZER | 1975-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088792-A1 | Pyridin-2-YL Methylamine Derivatives for Treating Opiate Dependence | OPRK1, OPRM1, OPRD1 | HTR1B 46/4885HTR1A 63/4885ADRB1 185/4885 |
| US-20100099709-A1 | PYRIDIN-2-YL-METHYLAMINE DERIVATIVES FOR TREATING OPIATE DEPENDENCE | OPRM1, OPRK1, OPRD1 | HTR1B 59/4885HTR1A 65/4885ADRB1 193/4885 |
| US-20050065348-A1 | Pyridin-2-yl-methylamine derivatives for treating opioid dependence | OPRM1, OPRK1, OPRD1 | HTR1B 51/4885HTR1A 59/4885ADRB1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.