Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.71 |
| ▸ | MMP2 | P08253 | 6/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | MMP14 | P50281 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576116 | 0.85 | XDH (0.56) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL8408444 | 0.83 | MMP13 (1.00) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL85706 | 0.81 | RAB9A (1.00) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL30994860 | 0.81 | RAB9A (1.00) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL68923 | 0.80 | HRH3 (0.84) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL829213 | 0.80 | KDM4E (0.76) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL829242 | 0.80 | KDM4E (0.76) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL30147570 | 0.80 | PIN1 (0.61) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL2925943 | 0.80 | PIN1 (0.61) | MMP13MMP2KDM4EALDH1A1HPGD | |
| SCHEMBL12862880 | 0.80 | PIN1 (0.45) | MMP13MMP2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |
| US-6441004-B1 | INDOLE DERIVATIVES AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 2002-08-27 | — | — | US | disclosed |
| CN-1265591-A | Coumpound | ZENECA LTD (GB) | 2000-09-06 | — | — | CN | disclosed |
| EP-1003504-A2 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | AstraZeneca UK Limited (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999007351-A2 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ZENECA LIMITED (GB) | 1999-02-18 | — | — | WO | disclosed |