Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 4/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082067 | 0.94 | RAB9A (0.39) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6042525 | 0.88 | RAB9A (0.39) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7079873 | 0.86 | REN (0.46) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7076956 | 0.86 | REN (0.41) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7080086 | 0.85 | REN (0.31) | REN | |
| SCHEMBL7076917 | 0.84 | REN (0.33) | REN | |
| SCHEMBL7079374 | 0.83 | MAPT (0.41) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7080839 | 0.83 | PDCD1 (0.38) | RENADAM17 | |
| SCHEMBL6041811 | 0.82 | RAB9A (0.42) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6958396 | 0.81 | RAB9A (0.45) | NPC1RAB9ATDP1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |