Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 3/20 | 0.41 |
| ▸ | KDM4B | O94953 | 3/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.41 |
| ▸ | KDM5C | P41229 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.41 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30620646 | 0.85 | ADORA3 (0.49) | HDAC1HDAC8HDAC6KDM4ENAPRT | |
| Potassium Ion SCHEMBL30620626 | 0.84 | HDAC1 (0.47) | HDAC1HDAC8HDAC6KDM4ENAPRT | |
| SCHEMBL5048867 | 0.82 | ECE1 (0.42) | KDM4EKDM4AKDM4BKDM5BKDM5C | |
| SCHEMBL3740171 | 0.77 | ADORA3 (0.58) | KDM4EADORA3KDM4AKDM4BKDM5B | |
| SCHEMBL10022668 | 0.75 | CYP19A1 (0.62) | KDM4ELMNAMEN1KMT2ANPC1 | |
| Bicarbonate SCHEMBL31484615 | 0.75 | HCAR2 (0.56) | HDAC1HDAC8HDAC6KDM4ENAPRT | |
| SCHEMBL5734275 | 0.74 | KDM4E (0.51) | KDM4EGRM1LMNACDC7DBF4 | |
| SCHEMBL6558546 | 0.72 | SPHK2 (0.46) | RAB9AALDH1A1CYP1A2 | |
| SCHEMBL5048865 | 0.72 | KDM4A (0.49) | HDAC1HDAC6KDM4EADORA3TSHR | |
| SCHEMBL6521674 | 0.72 | KDM4E (0.46) | HDAC1HDAC8HDAC6KDM4ENAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638953-B2 | Central nervous system disorders; anxiety | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-10-28 | — | — | US | disclosed |
| US-20030105139-A1 | Indole derivatives as 5-HT receptor antagonist | SMITHKLINE BEECHAM P.L.C. | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105139-A1 | Indole derivatives as 5-HT receptor antagonist | HTR5A, HTR2C, HTR1A | HDAC1 1480/4885HDAC8 1138/4885HDAC6 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.