Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 4/20 | 0.49 |
| ▸ | KDM4B | O94953 | 4/20 | 0.49 |
| ▸ | KDM5C | P41229 | 4/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ECE1 | P42892 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048867 | 0.84 | ECE1 (0.42) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL3740171 | 0.72 | ADORA3 (0.58) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL7080116 | 0.72 | HDAC1 (0.49) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL6558546 | 0.71 | SPHK2 (0.46) | ECE1ALDH1A1RAB9ACYP1A2 | |
| SCHEMBL7964249 | 0.71 | TSHR (0.50) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL167820 | 0.70 | RAB9A (0.58) | KDM4EHSD17B10NR1H4ALDH1A1RAB9A | |
| SCHEMBL15580281 | 0.70 | HDAC1 (0.53) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL31401011 | 0.70 | LMNA (0.55) | KDM4EHDAC6HDAC3HDAC1ALDH1A1 | |
| SCHEMBL3746725 | 0.70 | CSNK2A1 (0.56) | KDM4ENR1H4ALDH1A1RAB9ANPC1 | |
| SCHEMBL9286689 | 0.69 | ALDH1A1 (0.43) | KDM4AKDM4BKDM5CKDM5BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983980-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007087427-A2 | THIAZOLE AND THIADIAZOLE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | claimed |