Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975509 | 0.93 | RECQL (0.44) | RECQLLMNAS1PR3GRIN1GRIN2B | |
| SCHEMBL7086202 | 0.92 | LMNA (0.41) | LMNAS1PR3GRIN1GRIN2BNAMPT | |
| SCHEMBL7087801 | 0.91 | ROCK2 (0.36) | LMNAS1PR3GRIN1GRIN2BNAMPT | |
| SCHEMBL7085900 | 0.90 | ALDH1A1 (0.46) | RECQLLMNAS1PR3GRIN1GRIN2B | |
| SCHEMBL8109122 | 0.89 | RECQL (0.47) | RECQLLMNAS1PR3NAMPTKMT2A | |
| SCHEMBL6961326 | 0.89 | GRIN1 (0.39) | LMNAS1PR3GRIN1GRIN2BGAA | |
| SCHEMBL6963828 | 0.87 | GRIN1 (0.37) | LMNAGRIN1GRIN2BGAAKMT2A | |
| SCHEMBL6973446 | 0.87 | MAPT (0.42) | RECQLLMNANAMPTGAAKMT2A | |
| SCHEMBL7083464 | 0.87 | GRIN1 (0.39) | LMNAGRIN1GRIN2BGAAKMT2A | |
| SCHEMBL6974887 | 0.87 | GRIN1 (0.39) | GRIN1GRIN2BCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |