Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970855 | 0.91 | KCNA5 (0.53) | ALDH1A1KCNA5SMN1; SMN2MAPTRXFP1 | |
| SCHEMBL8042454 | 0.78 | KCNA5 (0.42) | ALDH1A1KCNA5SMN1; SMN2MAPTRXFP1 | |
| SCHEMBL6975922 | 0.76 | NPC1 (0.43) | ALDH1A1KCNA5SMN1; SMN2MAPTRXFP1 | |
| SCHEMBL6963364 | 0.76 | MEN1 (0.54) | ALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL6972549 | 0.75 | KMT2A (0.39) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL6977906 | 0.74 | CNR2 (0.40) | CA12CA1CA2CA9CA4 | |
| SCHEMBL6971590 | 0.74 | AKR1C3 (0.38) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL6967854 | 0.73 | PTPN11 (0.41) | ALDH1A1MAPT | |
| SCHEMBL6973904 | 0.73 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2MAPTRXFP1 | |
| SCHEMBL6978862 | 0.73 | HTR6 (0.36) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077947-B1 | NOVEL 1,5 AND 3-O-SUBSTITUTED 1H-INDAZOLES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY, IMMUNO-MODULATING AND NEURO-PROTECTIVE EFFECT, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | DRESDEN ARZNEIMITTEL (DE) | 2003-09-03 | — | — | EP | disclosed |