Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970836 | 0.89 | PKM (0.40) | MAPTPOLBCRBNL3MBTL1CYP3A4 | |
| SCHEMBL6970855 | 0.86 | KCNA5 (0.53) | KCNA5MAPTRXFP1ALDH1A1TP53 | |
| SCHEMBL8042460 | 0.83 | KCNA5 (0.39) | KCNA5MAPTPOLBRXFP1CYP3A4 | |
| SCHEMBL7080877 | 0.78 | ALDH1A1 (0.46) | KCNA5MAPTRXFP1ALDH1A1TP53 | |
| SCHEMBL6967908 | 0.75 | HTR6 (0.36) | MAPTL3MBTL1HTTALDH1A1 | |
| SCHEMBL6963364 | 0.73 | MEN1 (0.54) | MAPTPOLBCYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6975922 | 0.73 | NPC1 (0.43) | KCNA5MAPTPOLBRXFP1L3MBTL1 | |
| SCHEMBL6967437 | 0.73 | KMT2A (0.43) | MAPTALDH1A1 | |
| SCHEMBL6975974 | 0.72 | AKR1C3 (0.48) | MAPTL3MBTL1CYP2C9TP53 | |
| SCHEMBL6966615 | 0.71 | KMT2A (0.43) | MAPTRXFP1CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166023-A | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-26 | — | — | US | disclosed |