SCHEMBL7081177

SCHEMBL7081177

Clc1cccc([Si](Cl)(Cl)c2ccccc2)c1Cl

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.37
LMNA P02545 2/20 0.36
PNMT P11086 1/20 0.34
P2RX7 Q99572 7/20 0.33
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
IDO1 P14902 1/20 0.33
TDO2 P48775 1/20 0.33
CYP2A6 P11509 3/20 0.32
CYP1A2 P05177 2/20 0.32
MCOLN3 Q8TDD5 1/20 0.32
ALDH1A1 P00352 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5326981 0.81 TSHR (0.38) TSHRLMNAPNMTP2RX7MEN1
SCHEMBL22915607 0.78 ESR1 (0.41) TSHRLMNAPNMTP2RX7MEN1
SCHEMBL2103502 0.75 TSHR (0.44) TSHRLMNAPNMTMEN1KMT2A
SCHEMBL9932121 0.71 TSHR (0.41) TSHRLMNAPNMTIDO1CYP2A6
SCHEMBL29120692 0.71 TSHR (0.39) TSHRLMNAMAPTCYP1A2ALDH1A1
SCHEMBL76000 0.71 TSHR (0.39) TSHRLMNAMAPTCYP1A2ALDH1A1
SCHEMBL8207775 0.71 CYP1A2 (0.41) TSHRLMNAMAPTCYP2A6CYP1A2
SCHEMBL31643929 0.71 CYP1A2 (0.41) TSHRLMNAMAPTCYP2A6CYP1A2
SCHEMBL4264209 0.69 TDP1 (0.39) TSHRALDH1A1
SCHEMBL8372962 0.69 TSHR (0.50) TSHRLMNAPNMTMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0128721-B1 SILICA-MODIFIED CATALYST AND USE FOR SELECTIVE PRODUCTION OF PARA-DIALKYL SUBSTITUTED BENZENES MOBIL OIL CORPORATION (US) 1989-07-26 EP claimed
CN-105283415-B The in-situ modification coke selectivity of toluene disproportionation catalyst deactivates 埃克森美孚化学专利公司 2017-07-21 CN disclosed
CN-105283415-A In-situ trim coke selectivation of toluene disproportionation catalyst EXXONMOBIL CHEM PATENTS INC 2016-01-27 CN disclosed
CN-100579942-C Xylenes isomerization catalyst system and use thereof EXXONMOBIL CHEM PATENTS INC 2010-01-13 CN disclosed
CN-1989089-A Xylenes isomerization catalyst system and use thereof EXXONMOBIL CHEM PATENTS INC (US) 2007-06-27 CN disclosed
CN-1720207-A Aromatics conversion using ITQ-13 EXXONMOBIL CHEM PATENTS INC (US) 2006-01-11 CN disclosed
WO-2003059508-A1 REFORMING CATALYST AND PROCESS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2003-07-24 WO disclosed
US-20030136708-A1 Reforming catalyst and process EXXONMOBIL RESEARCH & ENGINEERING CO. 2003-07-24 US disclosed
US-6541408-B2 Progressive temperature gradient stabilizes hydrorefining catalysts (metal-modified zeolite) to allow long duration of use and low by-product make EXXONMOBIL OIL CORP. 2003-04-01 US disclosed
CN-1379698-A Zeolite bound catalyst containing at least three different zeolites, and use for hydrocarbon conversion EXXON MOBIL CHEM PATENTS INC (US) 2002-11-13 CN disclosed
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function EXXONMOBIL OIL CORPORATION 2002-07-11 US disclosed
CN-1356927-A Metal-contg. macrostructures of porous inorganic oxide, prepn. thereof, and use EXXON CHEMICAL PATENTS INC (US) 2002-07-03 CN disclosed
US-6346498-B1 PERMEATING METAL INTO MOLECULAR SIEVE; IN SITU SELECTIVATION WITH SILICON COMPOUND AND ROASTING; BY-PRODUCT INHIBITION EXXONMOBIL OIL CORPORATION 2002-02-12 US disclosed
US-6207871-B1 CONVERTING A HYDROCARBON FEEDSTREAM COMPRISING ETHYLBENZENE AND META-XYLENE OVER MOLECULAR SIEVE CATALYST UNDER ETHYLBENZENE CONVERSION CONDITIONS, MOBIL OIL CORPORATION 2001-03-27 US disclosed
US-4532368-A Passing mixture of phenol, ortho-alkylphenol, alkylating agent through zeolite catalyst, separating and recycling ortho-alkylphenols ETHYL CORPORATION (US) 1985-07-30 US disclosed
US-4444989-A Methylation of toluene to para-xylene catalyzed by crystalline silica E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-24 US disclosed
US-4283306-A CATALYTIC METHYLATION OF TOLUENE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function HDHD5, HSF1, HRH4 TSHR 4495/4885LMNA 2396/4885PNMT 923/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.