Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA6 | P23280 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074787 | 0.77 | LIMK1 (0.44) | CA1CA2CA4CA6ACHE | |
| SCHEMBL7077021 | 0.70 | HSP90AA1 (0.45) | ALDH1A1CYP3A4MAPTCYP2C19HSD17B10 | |
| SCHEMBL7107233 | 0.69 | HSP90AA1 (0.53) | ALDH1A1CYP3A4MAPTCYP2C19HSD17B10 | |
| SCHEMBL29771277 | 0.69 | ESR1 (0.43) | ALDH1A1CYP3A4MAPTCYP2C19HSD17B10 | |
| SCHEMBL2294178 | 0.69 | CA1 (0.73) | CA1CA2CA4CA6ALDH1A1 | |
| SCHEMBL7102544 | 0.69 | MAPT (0.53) | ALDH1A1CYP3A4MAPTCYP2C19HSD17B10 | |
| SCHEMBL27261519 | 0.69 | ESR1 (0.43) | ALDH1A1CYP3A4MAPTCYP2C19HSD17B10 | |
| SCHEMBL2914928 | 0.69 | DRD1 (0.58) | CA1CA2CA4CA6ALDH1A1 | |
| SCHEMBL3287680 | 0.69 | ALDH1A1 (0.56) | CA1CA2CA4CA6ALDH1A1 | |
| SCHEMBL29633762 | 0.69 | DRD1 (0.58) | CA1CA2CA4CA6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832891-B1 | Dihydrobenzo (B) indeno (2,1-D) thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2003-07-30 | — | — | EP | disclosed |
| EP-0832891-A1 | Dihydrobenzo (B) indeno (2,1-D) thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |