Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.56 |
| ▸ | P2RY10 | O00398 | 8/20 | 0.52 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.52 |
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345915 | 1.00 | NOD1 (0.56) | NOD1P2RY10GPR34DGKASLC1A3 | |
| SCHEMBL18974248 | 1.00 | NOD1 (0.56) | NOD1P2RY10GPR34DGKASLC1A3 | |
| Hydrochloric Acid SCHEMBL8725898 | 0.98 | NOD1 (0.55) | NOD1P2RY10GPR34DGKASLC1A3 | |
| SCHEMBL30557 | 0.95 | NOD1 (0.62) | NOD1P2RY10GPR34DGKAHTR2C | |
| SCHEMBL17537069 | 0.95 | NOD1 (0.62) | NOD1P2RY10GPR34DGKAHTR2C | |
| SCHEMBL4414480 | 0.94 | NOD1 (0.52) | NOD1P2RY10GPR34DGKADDAH1 | |
| SCHEMBL17537068 | 0.93 | NOD1 (0.64) | NOD1P2RY10GPR34DGKAHTR2C | |
| SCHEMBL17010720 | 0.93 | NOD1 (0.64) | NOD1P2RY10GPR34DGKAHTR2C | |
| SCHEMBL17537066 | 0.93 | NOD1 (0.64) | NOD1P2RY10GPR34DGKAHTR2C | |
| SCHEMBL7351258 | 0.93 | NOD1 (0.64) | NOD1P2RY10GPR34DGKAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220482-A1 | Novel peptide antagonist of CXCR4 derived from the N-terminus of the viral chemokine vMIP-II | HUANG ZIWEI (US) | 2003-11-27 | — | — | US | claimed |
| EP-1171152-A4 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | UNIV JEFFERSON (US) | 2002-09-25 | — | — | EP | claimed |
| EP-1171152-A1 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | Thomas Jefferson University (US) | 2002-01-16 | — | — | EP | claimed |
| WO-2001056591-A1 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | THOMAS JEFFERSON UNIVERSITY (US) | 2001-08-09 | — | — | WO | claimed |
| US-20170313676-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS, LTD. (CN) | 2017-11-02 | — | — | US | disclosed |
| EP-3214081-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Kangpu Biopharmaceuticals, Ltd. (CN) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016065980-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 康朴生物医药技术（上海）有限公司 | 2016-05-06 | — | — | WO | disclosed |
| CN-1256336-C | Novel 4'-demethyl-4'-0-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for preparation thereof and anti-cancer composition comprising same | KIM SONG BAE (KR) | 2006-05-17 | — | — | CN | disclosed |
| CN-1474822-A | Novel 4'-demethyl-4'-0-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for preparation thereof and anti-cancer composition comprising same | — | 2004-02-11 | — | — | CN | disclosed |
| US-20030220482-A1 | Novel peptide antagonist of CXCR4 derived from the N-terminus of the viral chemokine vMIP-II | HUANG ZIWEI (US) | 2003-11-27 | — | — | US | disclosed |
| EP-1171152-A4 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | UNIV JEFFERSON (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1171152-A1 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | Thomas Jefferson University (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2001056591-A1 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | THOMAS JEFFERSON UNIVERSITY (US) | 2001-08-09 | — | — | WO | disclosed |
| WO-1998022457-A9 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | — | 1998-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313676-A1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | IL2, IL1B, IL5 | NOD1 215/4885P2RY10 1278/4885GPR34 1936/4885 |
| US-20030220482-A1 | Novel peptide antagonist of CXCR4 derived from the N-terminus of the viral chemokine vMIP-II | CCL2, CCL5, CCR5 | NOD1 760/4885P2RY10 2645/4885GPR34 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.