SCHEMBL708348

SCHEMBL708348

COc1ccc(CN(Cc2ccc(OC)cc2)c2nccc(-c3ccc(-c4ccc(N(c5ccccc5)c5ccccc5)cc4)cc3)n2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.45
MAPT P10636 4/20 0.45
NOS1 P29475 1/20 0.44
CTSK P43235 1/20 0.44
CLK1 P49759 2/20 0.43
CLK2 P49760 2/20 0.43
DYRK1A Q13627 2/20 0.43
CLK4 Q9HAZ1 2/20 0.43
DYRK1B Q9Y463 2/20 0.43
CYP19A1 P11511 1/20 0.43
NPC1 O15118 2/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
TSHR P16473 3/20 0.42
ALDH1A1 P00352 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 2/20 0.42
CHRM2 P08172 1/20 0.42
CYP3A4 P08684 1/20 0.42
HTR1A P08908 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL709817 0.88 CTSK (0.43) LMNAMAPTNOS1CTSKKMT2A
SCHEMBL710351 0.87 CYP2C19 (0.46) CTSKCYP19A1MEN1KMT2ATSHR
SCHEMBL10972910 0.76 NPC1 (0.51) MAPTDYRK1ANPC1MEN1KMT2A
SCHEMBL708351 0.75 DYRK1A (0.48) CLK1CLK2DYRK1ACLK4DYRK1B
SCHEMBL13884017 0.74 LTA4H (0.65) MAPTCYP19A1NPC1MEN1KMT2A
SCHEMBL1106643 0.74 LTA4H (0.50) MAPTCYP19A1NPC1KMT2ASIGMAR1
SCHEMBL12677664 0.74 CA4 (0.52) LMNAMAPTNPC1KMT2AALDH1A1
SCHEMBL6139896 0.74 CA4 (0.52) LMNAMAPTNPC1KMT2AALDH1A1
SCHEMBL10057799 0.74 CA4 (0.52) LMNAMAPTNPC1KMT2AALDH1A1
SCHEMBL131837 0.74 CA4 (0.52) LMNAMAPTNPC1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8124762-B2 Diphenyl amine derivatives having luminescence property KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2012-02-28 US disclosed
US-8124762-B2 Diphenyl amine derivatives having luminescence property KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2012-02-28 US disclosed
US-8124762-B2 Diphenyl amine derivatives having luminescence property KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2012-02-28 US disclosed
US-20100063281-A1 DIPHENYL AMINE DERIVATIVES HAVING LUMINESCENCE PROPERTY KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2010-03-11 US disclosed
US-20100063281-A1 DIPHENYL AMINE DERIVATIVES HAVING LUMINESCENCE PROPERTY KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2010-03-11 US disclosed
US-20100063281-A1 DIPHENYL AMINE DERIVATIVES HAVING LUMINESCENCE PROPERTY KOREA INSTITUTE OF SCIENCE & TECHNOLOGY (KR) 2010-03-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100063281-A1 DIPHENYL AMINE DERIVATIVES HAVING LUMINESCENCE PROPERTY TYR, PNMT, DDC LMNA 2277/4885MAPT 137/4885NOS1 1153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.