Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 4/20 | 0.46 |
| ▸ | CES1 | P23141 | 4/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | PPARD | Q03181 | 7/20 | 0.43 |
| ▸ | PPARA | Q07869 | 7/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170615 | 0.98 | CES2 (0.48) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL9013815 | 0.79 | CES2 (0.54) | TDP1MEN1KMT2ACES2CES1 | |
| SCHEMBL13725818 | 0.76 | HSD17B3 (0.40) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL5579728 | 0.74 | TBXAS1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL2944337 | 0.74 | TBXAS1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL5966050 | 0.74 | TBXAS1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL20078981 | 0.74 | TBXAS1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL5580017 | 0.74 | TBXAS1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| SCHEMBL12661128 | 0.72 | MEN1 (0.47) | L3MBTL1TDP1MEN1KMT2ACES2 | |
| Benzene SCHEMBL28358854 | 0.69 | KMT2A (0.73) | TDP1MEN1KMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104069123-B | Xanthurenic acid (4,8-Er Qiangjikuilinjiasuan) derivatives medicinal composition and correlation technique thereof | 纳图龙公司 | 2016-10-05 | — | — | CN | disclosed |
| EP-1154996-B1 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | ORTHO MCNEIL PHARM INC (US) | 2003-11-05 | — | — | EP | disclosed |
| US-6369228-B2 | ANTICONVULSANTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-04-09 | — | — | US | disclosed |
| US-20010044452-A1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | CARSON JOHN R (US) | 2001-11-22 | — | — | US | disclosed |
| EP-1154996-A2 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | Ortho-McNeil Pharmaceutical, Inc. (US) | 2001-11-21 | — | — | EP | disclosed |
| US-6191142-B1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-02-20 | — | — | US | disclosed |
| WO-2000048584-A2 | AROYL AMINOACYL PYRROLES FOR USE IN THE TREATMENT OF NEUROPATHIC PAIN | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-08-24 | — | — | WO | disclosed |
| US-5332736-A | Anti-convulsant aroyl aminoacylpyrroles | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044452-A1 | Aroyl aminoacyl pyrroles for use in the treatment of neuropathic pain | OPRL1, AADAT, OPRK1 | L3MBTL1 4145/4885TDP1 2114/4885MEN1 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.