Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.32 |
| ▸ | ITGAL | P20701 | 4/20 | 0.32 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972940 | 0.95 | FAAH (0.35) | TDP1FAAHPIK3CDITGB2ICAM1 | |
| SCHEMBL6956997 | 0.91 | FAAH (0.36) | TDP1FAAHPIK3CDITGB2ICAM1 | |
| SCHEMBL6975892 | 0.90 | ALDH1A1 (0.36) | TDP1ALDH1A1FAAHTLR7ITGB2 | |
| SCHEMBL7083375 | 0.87 | FAAH (0.34) | FAAHPIK3CDTLR7ITGB2ICAM1 | |
| SCHEMBL6960043 | 0.85 | FAAH (0.35) | FAAHPIK3CDITGB2ICAM1ITGAL | |
| SCHEMBL6967535 | 0.84 | FAAH (0.35) | FAAHITGB2ICAM1ITGALERCC5 | |
| SCHEMBL6966431 | 0.83 | TP53 (0.37) | TDP1FAAHPIK3CDERCC5FEN1 | |
| SCHEMBL6966489 | 0.83 | TLR8 (0.35) | TDP1ALDH1A1TLR7 | |
| SCHEMBL6969844 | 0.83 | FAAH (0.36) | FAAHPIK3CDITGB2ICAM1ITGAL | |
| SCHEMBL6969270 | 0.83 | TLR7 (0.35) | TDP1ALDH1A1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |