Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3804440 | 0.86 | TRPA1 (0.33) | TSHRALDH1A1 | |
| SCHEMBL2582842 | 0.77 | CYP3A4 (0.33) | L3MBTL1ALDH1A1CYP3A4ALOX15SMN1; SMN2 | |
| SCHEMBL6933929 | 0.77 | ALDH1A1 (0.38) | TSHRALDH1A1 | |
| SCHEMBL8519698 | 0.74 | ALDH1A1 (0.32) | TSHRHPGDALDH1A1HSD17B10 | |
| SCHEMBL28110193 | 0.74 | KDM4E (0.39) | TSHRKDM4EMAPTRAB9APOLB | |
| SCHEMBL7141221 | 0.73 | GABRA1 (0.50) | GABRA1GABRB2TSHRKDM4EMAPT | |
| SCHEMBL10855944 | 0.73 | GABRA1 (0.50) | GABRA1GABRB2TSHRKDM4EMAPT | |
| SCHEMBL1052816 | 0.71 | TSHR (0.46) | TSHRKDM4EMAPTL3MBTL1HPGD | |
| SCHEMBL387118 | 0.71 | GABRA1 (0.48) | GABRA1GABRB2TSHRKDM4EMAPT | |
| SCHEMBL22144403 | 0.71 | TSHR (0.52) | GABRA1GABRB2TSHRKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4810814-A | Preparation of cyanoalkylphenols | THE DOW CHEMICAL COMPANY (US) | 1989-03-07 | — | — | US | claimed |
| US-4806673-A | Preparation of cyanoalkylphenols from bisphenols | THE DOW CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | claimed |
| US-6579871-B2 | Phenyl oxazoles or thiazoles | ELI LILLY AND COMPANY | 2003-06-17 | — | — | US | disclosed |
| EP-0971709-B1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | LILLY CO ELI (US) | 2003-05-21 | — | — | EP | disclosed |
| US-20030050311-A1 | Methods of using novel compounds as neuro-protective agents | PANETTA JILL ANN (US) | 2003-03-13 | — | — | US | disclosed |
| US-20020177595-A1 | Novel compounds useful as neuro-protective agents | PANETTA JILL ANN (US) | 2002-11-28 | — | — | US | disclosed |
| US-6472387-B1 | Methods of using compounds as neuro-protective agents | ELI LILLY AND COMPANY | 2002-10-29 | — | — | US | disclosed |
| US-6448396-B2 | 2-((3,5-DIALKYL-4-HYDROXYPHENYL-4-(2-(AMINOALKYLPHENOXY)ETHYL) OXAZOLES; ANTIISCHEMIC AGENTS; REPERFUSION INJURY OF PERIPHERAL ORGANS; FREE RADICAL ANTAGONISTS; PARKINSON'S AND ALZHEIMER'S DISESES; DOWN'S SYNDROME; AMYOTROPHIC LATERAL S. | ELI LILLY AND COMPANY | 2002-09-10 | — | — | US | disclosed |
| US-6423709-B1 | FOR THERAPY OF ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AMYTROPHIC LATERAL SCLEROSIS OR CEREBRAL TRAUMA IN A MAMMAL | ELI LILLY AND COMPANY | 2002-07-23 | — | — | US | disclosed |
| US-20020065274-A1 | METHODS OF USING NOVEL COMPOUNDS AS NEURO-PROTECTIVE AGENTS | PANETTA JILL ANN (US) | 2002-05-30 | — | — | US | disclosed |
| US-6380213-B1 | PHENYL OXAZOLES, THIAZOLES, OXAZOLINES, OXADIAZOLES AND BENZOXAZOLES | ELI LILLY AND COMPANY | 2002-04-30 | — | — | US | disclosed |
| WO-1999009979-A1 | METHOD FOR TREATING NEUROPATHIC PAIN | ELI LILLY AND COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |
| WO-1998015274-A1 | NOVEL COMPOUNDS USEFUL AS NEURO-PROTECTIVE AGENTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| US-4916251-A | Cyanoisoalkylation of hydroxy substituted aryl compounds using ketones | THE DOW CHEMICAL COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| US-4810814-A | Preparation of cyanoalkylphenols | THE DOW CHEMICAL COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| US-4810814-A | Preparation of cyanoalkylphenols | THE DOW CHEMICAL COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| US-4810814-A | Preparation of cyanoalkylphenols | THE DOW CHEMICAL COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| US-4806673-A | Preparation of cyanoalkylphenols from bisphenols | THE DOW CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| US-4806673-A | Preparation of cyanoalkylphenols from bisphenols | THE DOW CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| US-4806673-A | Preparation of cyanoalkylphenols from bisphenols | THE DOW CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177595-A1 | Novel compounds useful as neuro-protective agents | NLN, PRDX5, TXN2 | GABRA1 99/4885GABRB2 26/4885TSHR 3826/4885 |
| US-20020065274-A1 | METHODS OF USING NOVEL COMPOUNDS AS NEURO-PROTECTIVE AGENTS | NLN, GAP43, TXN2 | GABRA1 171/4885GABRB2 36/4885TSHR 3856/4885 |
| US-20030050311-A1 | Methods of using novel compounds as neuro-protective agents | NLN, GAP43, TXN2 | GABRA1 171/4885GABRB2 36/4885TSHR 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.