Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP4 | P49662 | 1/20 | 0.48 |
| ▸ | CASP5 | P51878 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085731 | 0.88 | HTR6 (0.53) | SIGMAR1LMNAHTR6TSHRHTR1A | |
| SCHEMBL1537840 | 0.77 | HTR6 (0.78) | HTR6HTR1ADRD2 | |
| SCHEMBL7086820 | 0.74 | HTR6 (0.55) | HTR6DRD2 | |
| SCHEMBL8570664 | 0.73 | SIGMAR1 (0.81) | SIGMAR1LMNATSHRDRD2ALDH1A1 | |
| SCHEMBL20804357 | 0.73 | SIGMAR1 (0.90) | SIGMAR1LMNAHTTTSHRHTR1A | |
| SCHEMBL28186295 | 0.73 | SIGMAR1 (0.90) | SIGMAR1LMNAHTTTSHRHTR1A | |
| SCHEMBL4304442 | 0.71 | HTR6 (0.54) | HTR6HTR1ADRD2 | |
| SCHEMBL8174066 | 0.71 | SIGMAR1 (0.71) | SIGMAR1LMNATSHRHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL4316251 | 0.70 | HTR6 (0.53) | HTR6HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL6521806 | 0.70 | HTR6 (0.53) | HTR6HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343756-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002036562-A2 | 1-ARYL- OR 1-ALKYLSULFONYL-HETEROCYCLYLBENZAZOLES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-05-10 | — | — | WO | disclosed |