Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7082343 | 0.93 | GRIN1 (0.32) | GRIN1GRIN2BENPP2LMNATP53 | |
| SCHEMBL6975545 | 0.93 | GRIN1 (0.34) | GRIN1GRIN2BENPP2LMNATP53 | |
| SCHEMBL6973130 | 0.93 | ENPP2 (0.32) | ENPP2GRM5MEN1KMT2A | |
| SCHEMBL6973952 | 0.92 | ENPP2 (0.36) | GRIN1GRIN2BENPP2LMNATP53 | |
| SCHEMBL6960775 | 0.91 | GRIN1 (0.35) | GRIN1GRIN2BLMNAMAPTALDH1A1 | |
| SCHEMBL6973001 | 0.91 | P2RX3 (0.33) | LMNATP53GSK3BROCK2ROCK1 | |
| SCHEMBL6975778 | 0.90 | MEN1 (0.36) | ENPP2TP53MAPTGSK3BCYP2C9 | |
| SCHEMBL7084285 | 0.89 | GRIN1 (0.33) | GRIN1GRIN2BLMNATP53GRM5 | |
| SCHEMBL7084536 | 0.88 | DHODH (0.33) | LMNAMAPTCYP2C9CYP1A2CYP2C19 | |
| SCHEMBL6967391 | 0.88 | KMT2A (0.35) | LMNAMAPTCYP2C9CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |