Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084307 | 0.90 | SMN1; SMN2 (0.44) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL6968447 | 0.87 | CA2 (0.38) | LMNAHTTALDH1A1 | |
| SCHEMBL6972417 | 0.87 | TP53 (0.39) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL7084970 | 0.86 | MAPT (0.37) | MEN1KMT2ASMN1; SMN2RECQLTP53 | |
| SCHEMBL6961674 | 0.85 | TP53 (0.39) | LMNAMEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL7082939 | 0.84 | SMN1; SMN2 (0.31) | LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6961868 | 0.84 | F2 (0.31) | LMNAHTTALDH1A1MAPT | |
| SCHEMBL6974137 | 0.84 | CYP2C9 (0.32) | LMNAHTTRECQL | |
| SCHEMBL7082911 | 0.84 | ALDH1A1 (0.40) | MEN1KMT2ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL7079372 | 0.84 | IRAK4 (0.38) | LMNAKMT2ASMN1; SMN2RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |