Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70873 | 0.77 | CFTR (0.50) | NOTUMALDH1A1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4659258 | 0.75 | GAA (0.40) | ALDH1A1KDM4E | |
| SCHEMBL70047 | 0.74 | NOTUM (0.65) | NOTUMALDH1A1KMT2AHPGDKDM4E | |
| SCHEMBL7957854 | 0.74 | CES2 (0.31) | NOTUMCES2 | |
| SCHEMBL1930232 | 0.74 | ALDH1A1 (0.45) | NOTUMASPHALDH1A1KMT2AHPGD | |
| SCHEMBL15920412 | 0.73 | ASPH (0.53) | NOTUMASPHALDH1A1TAS2R14CLCN2 | |
| SCHEMBL3036944 | 0.73 | ASPH (0.59) | NOTUMASPHALDH1A1TAS2R14HPGD | |
| SCHEMBL70872 | 0.72 | TAS2R14 (0.41) | NOTUMASPHALDH1A1TAS2R14FABP4 | |
| SCHEMBL30748715 | 0.71 | ASPH (0.57) | NOTUMASPHALDH1A1TAS2R14HPGD | |
| Hydrochloric Acid SCHEMBL22164128 | 0.71 | ASPH (0.57) | NOTUMASPHALDH1A1TAS2R14HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101367794-B | Preparation method for quinazoline derivants and medical uses thereof | SHANGHAI HENGRUI PHARM CO LTD | 2013-07-10 | — | — | CN | disclosed |
| CN-101367794-A | Preparation method for quinazoline derivants and medical uses thereof | SHANGHAI HENGRUI PHARM CO LTD (CN) | 2009-02-18 | — | — | CN | disclosed |
| EP-0176387-B1 | PYRROLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PESTICIDES | ROUSSEL-UCLAF (FR) | 1990-11-22 | — | — | EP | disclosed |
| EP-0176387-A1 | Pyrrole derivatives, process for their preparation and their application as pesticides | ROUSSEL-UCLAF (FR) | 1986-04-02 | — | — | EP | disclosed |