2-Pyrrolidone

2-Pyrrolidone

SCHEMBL8965954

C=C(C)C(=O)ONC.O=C1CCCN1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.48
CRBN Q96SW2 2/20 0.42
FKBP5 Q13451 1/20 0.42
ALDH1A1 P00352 2/20 0.35
KDM4E B2RXH2 2/20 0.33
GAA P10253 1/20 0.33
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.31
GFER P55789 1/20 0.31
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31
MMP1 P03956 1/20 0.31
MMP9 P14780 1/20 0.31
ADAM17 P78536 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Pyrrolidone SCHEMBL7090022 0.87 ALDH1A1 (0.52) OR51E2CRBNFKBP5ALDH1A1KDM4E
Caprolactam SCHEMBL28170750 0.81 CRBN (0.52) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL27365042 0.79 OR51E2 (0.47) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL8133376 0.79 OR51E2 (0.47) OR51E2CRBNFKBP5ALDH1A1POLB
2-Pyrrolidone SCHEMBL28134430 0.79 OR51E2 (0.47) OR51E2CRBNFKBP5ALDH1A1KDM4E
Methacrylic Acid SCHEMBL183419 0.79 OR51E2 (0.60) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL28258038 0.78 OR51E2 (0.71) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL28304483 0.78 OR51E2 (0.46) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL17241782 0.78 OR51E2 (0.46) OR51E2CRBNFKBP5ALDH1A1KDM4E
2-Pyrrolidone SCHEMBL12468588 0.78 OR51E2 (0.46) OR51E2CRBNFKBP5KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5554388-A CATIONIC POLYMER DANBIOSYST UK LIMITED (GB) 1996-09-10 US claimed