Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090105 | 1.00 | NPC1 (0.46) | NPC1RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL7093380 | 0.85 | NPSR1 (0.43) | NPC1RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL7093379 | 0.85 | NPSR1 (0.43) | NPC1RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL7092979 | 0.81 | ALDH1A1 (0.42) | NPC1RAB9AL3MBTL1GAANPSR1 | |
| SCHEMBL7092976 | 0.81 | ALDH1A1 (0.42) | NPC1RAB9AL3MBTL1GAANPSR1 | |
| SCHEMBL7091213 | 0.74 | RAB9A (0.49) | NPC1RAB9AL3MBTL1TDP1ALOX15 | |
| SCHEMBL7091215 | 0.74 | RAB9A (0.49) | NPC1RAB9AL3MBTL1TDP1ALOX15 | |
| SCHEMBL28910418 | 0.74 | NPSR1 (0.50) | NPC1RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL9659781 | 0.72 | NPC1 (0.53) | NPC1RAB9AL3MBTL1GAAHDAC6 | |
| SCHEMBL1002786 | 0.72 | HPGD (0.67) | NPC1RAB9AGAAHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | claimed |
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | disclosed |