SCHEMBL7090499

SCHEMBL7090499

O=C(O)c1ccc(Oc2ccc(C(F)(F)F)cc2)nc1

nearest known ligand 0.65

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.65
L3MBTL1 Q9Y468 2/20 0.60
LIPE Q05469 12/20 0.58
RAB9A P51151 2/20 0.57
MAPT P10636 2/20 0.55
NPSR1 Q6W5P4 2/20 0.55
CYP3A4 P08684 1/20 0.55
GAA P10253 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
HTT P42858 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
BCHE P06276 1/20 0.52
NPC1 O15118 1/20 0.52
TNF P01375 1/20 0.52
NOD1 Q9Y239 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4327207 0.91 LMNA (0.73) LMNALIPERAB9AMAPTNPSR1
SCHEMBL21656856 0.89 LMNA (0.55) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL21656517 0.89 LMNA (0.55) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL21628911 0.87 LMNA (0.64) LMNALIPERAB9AMAPTNPSR1
SCHEMBL21656820 0.86 LMNA (0.53) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL19362910 0.85 RAB9A (0.60) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL21656969 0.85 LMNA (0.52) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL3133529 0.85 RAB9A (0.71) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL1437114 0.85 LMNA (0.85) LMNAL3MBTL1LIPERAB9AMAPT
SCHEMBL20482700 0.85 LMNA (0.64) LMNAL3MBTL1LIPERAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-12-21 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2022-11-03 US disclosed
US-11178872-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2021-11-23 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20190191702-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2019-06-27 US disclosed
EP-3456716-A1 RING-SHAPED AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2019-03-20 EP disclosed
WO-2017195703-A1 RING-SHAPED AMINE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2017-11-16 WO disclosed
EP-1093367-A4 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2003-03-05 EP disclosed
EP-1093367-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2001-04-25 EP disclosed
WO-1999066925-A1 PROTEASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1999-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885L3MBTL1 670/4885LIPE 4438/4885
US-20190191702-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT H1-4, H1-10, NPR1 LMNA 3087/4885L3MBTL1 41/4885LIPE 2112/4885
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885L3MBTL1 670/4885LIPE 4438/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK LMNA 3083/4885L3MBTL1 854/4885LIPE 4390/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885L3MBTL1 670/4885LIPE 4438/4885
US-11178872-B2 Cyclic amine compound and pest control agent H1-4, H1-10, NPR1 LMNA 3087/4885L3MBTL1 41/4885LIPE 2112/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR LMNA 832/4885L3MBTL1 116/4885LIPE 2500/4885
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885L3MBTL1 670/4885LIPE 4438/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885L3MBTL1 670/4885LIPE 4438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.