Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12733099 | 0.79 | PKM (0.57) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL6871340 | 0.79 | PKM (0.57) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL5891307 | 0.76 | PKM (0.50) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL28961728 | 0.75 | PKM (0.58) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL5891385 | 0.74 | PKM (0.43) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL15145002 | 0.71 | PKM (0.62) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL15974322 | 0.70 | MMP8 (0.37) | PKMKDM4ETHRBMAPTMEN1 | |
| SCHEMBL27784023 | 0.70 | PKM (0.47) | PKMKDM4ETHRBHTTMAPT | |
| SCHEMBL15468407 | 0.69 | ALDH1A1 (0.40) | KDM4ETHRBMAPTMEN1KMT2A | |
| SCHEMBL3284442 | 0.69 | ALDH1A1 (0.42) | THRBHTTMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858464-B1 | THROMBIN INHIBITORS | AKZO NOBEL NV (NL) | 2003-05-07 | — | — | EP | disclosed |
| US-20020142967-A1 | Thrombin inhibitors | ADANG A E P (NL) | 2002-10-03 | — | — | US | disclosed |
| US-6432921-B2 | OLIGOPEPTIDES | AKZO NOBEL N.V. (NL) | 2002-08-13 | — | — | US | disclosed |
| US-20010007764-A1 | THROMBIN INHIBITORS | N.V. ORGANON (NL) | 2001-07-12 | — | — | US | disclosed |
| US-6218365-B1 | FOR TREATING OR PREVENTING A THROMBIN-RELATED DISEASE | AKZO NOBEL N.V. (NL) | 2001-04-17 | — | — | US | disclosed |
| EP-1012164-A1 | SERINE PROTEASE INHIBITORS | Akzo Nobel N.V. (NL) | 2000-06-28 | — | — | EP | disclosed |
| EP-0858464-A1 | THROMBIN INHIBITORS | Akzo Nobel N.V. (NL) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997031939-A1 | SERINE PROTEASE INHIBITORS | AKZO NOBEL N.V. (NL) | 1997-09-04 | — | — | WO | disclosed |
| WO-1997017363-A1 | THROMBIN INHIBITORS | AKZO NOBEL N.V. (NL) | 1997-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020142967-A1 | Thrombin inhibitors | SERPINC1, DAO, CTRL | PKM 4517/4885KDM4E 3463/4885THRB 86/4885 |
| US-20010007764-A1 | THROMBIN INHIBITORS | SERPINC1, DAO, F2 | PKM 3909/4885KDM4E 3147/4885THRB 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.