Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL482553 | 0.98 | ENPP1 (0.44) | ENPP1MEN1KMT2APOLBPTGS2 | |
| Bromide SCHEMBL3139959 | 0.96 | ENPP1 (0.43) | ENPP1MEN1KMT2APOLBPTGS2 | |
| Perchlorate SCHEMBL3135944 | 0.89 | ENPP1 (0.39) | ENPP1MEN1KMT2APOLBPTGS2 | |
| SCHEMBL3144542 | 0.82 | LMNA (0.44) | MEN1KMT2APOLBPTGS2PTGS1 | |
| Trifluoromethanesulfonic Acid SCHEMBL1088677 | 0.81 | ENPP1 (0.43) | ENPP1MEN1KMT2APOLBPTGS2 | |
| Iodide SCHEMBL6930685 | 0.80 | ADORA2A (0.38) | PTGS2PTGS1NPC1RAB9ATP53 | |
| SCHEMBL28677960 | 0.79 | ENPP1 (0.35) | ENPP1NPC1RAB9AADORA3ACHE | |
| SCHEMBL7901498 | 0.79 | PTGS2 (0.40) | ENPP1PTGS2PTGS1AKR1C3AKR1C2 | |
| SCHEMBL7266829 | 0.79 | PDCD1 (0.38) | ENPP1MEN1KMT2APOLBNPC1 | |
| SCHEMBL946982 | 0.79 | MEN1 (0.44) | ENPP1MEN1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1160095-B1 | Heat-sensitive composition and planographic printing plate precursor | FUJIFILM CORP (JP) | 2013-12-25 | — | — | EP | disclosed |
| US-6660446-B2 | Generating acid upon heating | FUJI PHOTO FILM CO., LTD. (JP) | 2003-12-09 | — | — | US | disclosed |
| US-20020025489-A1 | Generating acid upon heating | FUJIFILM CORPORATION (JP) | 2002-02-28 | — | — | US | disclosed |
| EP-1160095-A2 | Heat-sensitive composition and planographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2001-12-05 | — | — | EP | disclosed |