Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.45 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.45 |
| ▸ | RPS17 | P08708 | 1/20 | 0.45 |
| ▸ | RPSA | P08865 | 1/20 | 0.45 |
| ▸ | RPS2 | P15880 | 1/20 | 0.45 |
| ▸ | RPL35A | P18077 | 1/20 | 0.45 |
| ▸ | RPL7 | P18124 | 1/20 | 0.45 |
| ▸ | RPL17 | P18621 | 1/20 | 0.45 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.45 |
| ▸ | RPS3 | P23396 | 1/20 | 0.45 |
| ▸ | RPS12 | P25398 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14568970 | 1.00 | LMNA (0.66) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL12683703 | 0.86 | LMNA (0.65) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL9836784 | 0.85 | ALDH1A1 (0.65) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL12683627 | 0.84 | LMNA (0.67) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL12413849 | 0.84 | LMNA (0.71) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL12494026 | 0.84 | LMNA (0.67) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL14880947 | 0.84 | LMNA (0.67) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL9092856 | 0.82 | LMNA (0.67) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL14183019 | 0.82 | LMNA (0.67) | LMNACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL14880790 | 0.81 | LMNA (0.70) | LMNACYP3A4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003093221-A1 | PREPARATION OF D-(-) -1-SUBSTITUTED PHENYL-2-DICHLORO-ACETOAMINO-3FLUORO-1-PROPANOL FROM L TYPE SUBSTITUTED PHENYL SERINE ESTER | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2003-11-13 | — | — | WO | disclosed |
| EP-0014437-B1 | NOVEL 1-ARYL-2-ACYLAMIDO-3-FLUORO-1-PROPANOLS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4361557-A | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor | SCHERING CORPORATION (US) | 1982-11-30 | — | — | US | disclosed |
| US-4311857-A | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor | SCHERING CORPORATION (US) | 1982-01-19 | — | — | US | disclosed |
| US-4235892-A | AROMATIC ANTIBIOTICS | Schering Corporation, Patent Dept. (US) | 1980-11-25 | — | — | US | disclosed |
| EP-0014437-A2 | Novel 1-aryl-2-acylamido-3-fluoro-1-propanols, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1980-08-20 | — | — | EP | disclosed |