Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28252352 | 0.80 | TDP1 (0.55) | ALDH1A1RORCCYP1A2CYP2C19NPSR1 | |
| SCHEMBL7091504 | 0.78 | NR3C1 (0.48) | NR3C1CYP1A2RAB9A | |
| SCHEMBL28518947 | 0.77 | RORC (0.51) | ALDH1A1RORCCYP1A2CYP2C19NPSR1 | |
| SCHEMBL1851780 | 0.75 | SMN1; SMN2 (0.68) | ALDH1A1CYP1A2CYP2C19POLBHTT | |
| SCHEMBL30492996 | 0.75 | SMN1; SMN2 (0.68) | ALDH1A1CYP1A2CYP2C19POLBHTT | |
| SCHEMBL7092393 | 0.74 | NPC1 (0.42) | ALDH1A1NPSR1POLBHTTMEN1 | |
| SCHEMBL829610 | 0.74 | TGM2 (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL28520661 | 0.73 | CYP1A2 (0.43) | ALDH1A1CYP1A2CYP2C19NPSR1POLB | |
| SCHEMBL5952099 | 0.72 | ALDH1A1 (0.62) | ALDH1A1RORCPOLBHTTMEN1 | |
| SCHEMBL13414995 | 0.72 | SMN1; SMN2 (0.52) | ALDH1A1CYP1A2CYP2C19NPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665843-B1 | SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS | PFIZER (US) | 2003-08-13 | — | — | EP | disclosed |
| US-5837711-A | Substituted quinuclidines as substance P antagonists | PFIZER INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0665843-A1 | SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1995-08-09 | — | — | EP | disclosed |
| WO-1994010170-A1 | SUBSTITUTED QUINUCLIDINES AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |