Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19736135 | 0.81 | GRM5 (0.50) | KDM4ELMNAPTK2MAPK8L3MBTL1 | |
| SCHEMBL9753194 | 0.81 | SORT1 (0.53) | KDM4ELMNAPTK2ALDH1A1NPC1 | |
| SCHEMBL2019170 | 0.78 | KDM4E (0.46) | KDM4ELMNAPTK2ALDH1A1NPC1 | |
| SCHEMBL28545686 | 0.78 | PTK2 (0.51) | KDM4ELMNAPTK2NPC1RAB9A | |
| SCHEMBL9974219 | 0.78 | KDM4E (0.46) | KDM4ELMNAPTK2ALDH1A1NPC1 | |
| SCHEMBL1269767 | 0.78 | RAB9A (0.60) | SMN1; SMN2KDM4ELMNAALDH1A1NPC1 | |
| SCHEMBL12513100 | 0.76 | MAPK8 (0.47) | KDM4ELMNAPTK2ALDH1A1NPC1 | |
| SCHEMBL9753618 | 0.75 | ALDH1A1 (0.56) | SMN1; SMN2KDM4ELMNAALDH1A1NPC1 | |
| SCHEMBL14878851 | 0.75 | KDM4E (0.44) | SMN1; SMN2KDM4ELMNAPTK2ALDH1A1 | |
| SCHEMBL12435247 | 0.75 | KDM4E (0.44) | SMN1; SMN2KDM4ELMNAPTK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842924-B1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER (US) | 2003-08-20 | — | — | EP | claimed |
| EP-0842924-A1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER INC. (US) | 1998-05-20 | — | — | EP | claimed |
| EP-0842924-B1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER (US) | 2003-08-20 | — | — | EP | disclosed |
| US-6031105-A | Substituted pyridines | PFIZER INC (US) | 2000-02-29 | — | — | US | disclosed |
| US-6008361-A | Substituted pyridines | PFIZER INC. (US) | 1999-12-28 | — | — | US | disclosed |
| EP-0842924-A1 | Pyridine intermediates, useful in the synthesis of beta-adrenergic receptor agonists | PFIZER INC. (US) | 1998-05-20 | — | — | EP | disclosed |