Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4628703 | 0.81 | ALDH1A1 (0.59) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL28331942 | 0.78 | LMNA (0.55) | ALDH1A1HDAC1HDAC6NPC1RAB9A | |
| SCHEMBL6744159 | 0.78 | MEN1 (0.52) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1406436 | 0.77 | CA1 (0.58) | ALDH1A1GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL554489 | 0.77 | ALOX15 (0.56) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL2567668 | 0.77 | ALDH1A1 (0.73) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL7103221 | 0.77 | ALDH1A1 (1.00) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL5691186 | 0.77 | ALDH1A1 (0.73) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL3993028 | 0.75 | LMNA (0.59) | ALDH1A1GAAHDAC1HDAC6NPC1 | |
| SCHEMBL93662 | 0.75 | HDAC6 (1.00) | ALDH1A1GAAHDAC1HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6359061-B1 | COMBINATORIAL LIBRARIES ARE USEFUL FOR SCREENING IN BIOLOGCAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | claimed |
| US-6613814-B2 | Water-dispersed particles of an oil-soluble pyrrolotriazol-azomethine dyes and an oil-soluble polymer; reproduction, especially cyan color; waterproofing; colorfastness; storage stability; antifouling agents; paper | FUJI PHOTO FILM CO., LTD. (JP) | 2003-09-02 | — | — | US | disclosed |
| US-6359061-B1 | COMBINATORIAL LIBRARIES ARE USEFUL FOR SCREENING IN BIOLOGCAL ASSAYS IN ORDER TO IDENTIFY PHARMACEUTICALLY USEFUL COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-20010020055-A1 | Coloring composition, ink for ink jet, and ink jet recording method | FUJIFILM CORPORATION (JP) | 2001-09-06 | — | — | US | disclosed |
| EP-0903350-A1 | Pyrrolotriazole derivative | FUJI PHOTO FILM CO., LTD. (JP) | 1999-03-24 | — | — | EP | disclosed |
| US-5523410-A | Intermediate for synthesis and production of amino acid derivative | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| US-5508421-A | Pyrrolotriazole azomethine dye, and heat transfer dye providing material containing a pyrrolotriazole azomethine dye | FUJI PHOTO FILM CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0648747-A1 | NOVEL INTERMEDIATE FOR SYNTHESIS AND PRODUCTION OF AMINO ACID DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994025062-A1 | ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING RENIN INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-10 | — | — | WO | disclosed |
| US-5227359-A | Pyrazoloazole dyes | FUJI PHOTO FILM CO., LTD. (JP) | 1993-07-13 | — | — | US | disclosed |
| WO-1993012796-A1 | USE OF RENIN INHIBITORS FOR THE TREATMENT OF GLAUCOMA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-08 | — | — | WO | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5210200-A | Fast to heat and light | FUJI PHOTO FILM CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0518238-A1 | Pyrrolotriazole derivative | FUJI PHOTO FILM CO., LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-5128312-A | Thermal transfer dye donating material | FUJI PHOTO FILM CO., LTD. (JP) | 1992-07-07 | — | — | US | disclosed |
| US-4975409-A | Ketone imine dyes; colorfastness; copies | FUJI PHOTO FILM CO., LTD. (JP) | 1990-12-04 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |