Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 6/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12620628 | 0.88 | HDAC6 (0.77) | HDAC6HDAC1ALDH1A1GAAHDAC8 | |
| SCHEMBL676148 | 0.88 | RAB9A (0.85) | HDAC6HDAC1ALDH1A1HDAC8HDAC2 | |
| SCHEMBL21628916 | 0.88 | HDAC6 (0.77) | HDAC6HDAC1ALDH1A1GAAHDAC8 | |
| SCHEMBL3673435 | 0.87 | HDAC6 (0.75) | HDAC6HDAC1HDAC8HDAC2CA1 | |
| SCHEMBL19193084 | 0.86 | HDAC6 (0.74) | HDAC6HDAC1ALDH1A1GAAHDAC8 | |
| SCHEMBL12620650 | 0.86 | HDAC6 (0.74) | HDAC6HDAC1ALDH1A1GAAHDAC8 | |
| SCHEMBL7103221 | 0.82 | ALDH1A1 (1.00) | HDAC6HDAC1ALDH1A1GAANPC1 | |
| SCHEMBL2567668 | 0.82 | ALDH1A1 (0.73) | HDAC6HDAC1ALDH1A1GAANPC1 | |
| SCHEMBL5691186 | 0.82 | ALDH1A1 (0.73) | HDAC6HDAC1ALDH1A1GAANPC1 | |
| SCHEMBL5391604 | 0.82 | HDAC6 (0.67) | HDAC6HDAC1ALDH1A1GAAHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981648-B2 | Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones | TESLA, INC. (US) | 2024-05-14 | — | — | US | claimed |
| CN-114195772-B | 1,2, 4-oxadiazole derivative containing 1,3, 4-thiadiazole unit, and preparation method and application thereof | 贵州大学 | 2023-06-30 | — | — | CN | claimed |
| US-20230029852-A1 | METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES | PANASONIC HOLDINGS CORPORATION (JP) | 2023-02-02 | — | — | US | claimed |
| CN-110653071-B | Rare earth collecting agent and preparation method thereof | 内蒙古包钢稀土林峰科技有限公司 | 2021-06-29 | — | — | CN | claimed |
| CN-110653071-A | Rare earth collecting agent and preparation method thereof | 内蒙古包钢稀土林峰科技有限公司 | 2020-01-07 | — | — | CN | claimed |
| EP-1461010-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | Integriderm, Inc. (US) | 2004-09-29 | — | — | EP | claimed |
| US-20030199558-A1 | Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners | INTEGRIDERM, INC. | 2003-10-23 | — | — | US | claimed |
| WO-2003057184-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | INTEGRIDERM, INC. (US) | 2003-07-17 | — | — | WO | claimed |
| US-20250297134-A1 | HIGH RATE BULK OXIDE CMP COMPOSITION | ENTEGRIS, INC. | 2025-09-25 | — | — | US | disclosed |
| CN-119591676-A | Lipopeptide HIV membrane fusion inhibitor and pharmaceutical application | 中国医学科学院病原生物学研究所 | 2025-03-11 | — | — | CN | disclosed |
| CN-118724753-A | Method for promoting synthesis of hydroxamic acid by using metal salt | 沈阳药科大学 | 2024-10-01 | — | — | CN | disclosed |
| WO-2024123929-A1 | DEVELOPMENT OF POTENT DUAL HDAC/BRD4 INHIBITORS | BIOVENTURES, LLC (US) | 2024-06-13 | — | — | WO | disclosed |
| CN-115160097-B | Method for synthesizing amide by reducing N-O bond by thioacetic acid | 温州大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-118027033-A | HDAC6 inhibitor, preparation method thereof and application thereof in anti-inflammatory and ulcerative colitis | 四川大学 | 2024-05-14 | — | — | CN | disclosed |
| EP-1461010-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | Integriderm, Inc. (US) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003057184-A2 | HYDROXAMIC ACID AND ITS DERIVATIVES AS INHIBITORS OF MELANOCYTE TYROSINASE FOR TOPICAL SKIN LIGHTENERS | INTEGRIDERM, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| EP-1052661-A2 | Metal complex dye for a photoelectrochemical cell | FUJI PHOTO FILM CO., LTD. (JP) | 2000-11-15 | — | — | EP | disclosed |
| US-4999366-A | Treatment of hyperlipidemia | THE NORTH CAROLINA CENTRAL UNIV. (US) | 1991-03-12 | — | — | US | disclosed |
| US-4946963-A | HYPOLIPIDEMIC AGENTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0321090-A2 | Isoxazolidine-3,5-diones in the treatment of hyperlipidemia | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1989-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199558-A1 | Hydroxamic acid and its derivatives as inhibitors of melanocyte tyrosinase for topical skin lighteners | TYR, MC1R, MITF | HDAC6 647/4885HDAC1 466/4885ALDH1A1 306/4885 |
| US-11981648-B2 | Method for the synthesis of 3-R-1,4,2-dioxazol-5-ones | CYP4X1, DDO, CYP4B1 | HDAC6 1947/4885HDAC1 1595/4885ALDH1A1 269/4885 |
| US-20230029852-A1 | METHOD FOR THE SYNTHESIS OF 3-R-1,4,2-DIOXAZOL-5-ONES | CYP4X1, DDO, CYP4B1 | HDAC6 1947/4885HDAC1 1595/4885ALDH1A1 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.