Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PLTP | P55058 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27598406 | 0.94 | PLTP (0.41) | TRPV4MAPTLMNATP53PDE4A | |
| SCHEMBL29403637 | 0.88 | TRPV4 (0.36) | TRPV4MAPTLMNATP53PLTP | |
| SCHEMBL6698972 | 0.88 | TRPV4 (0.34) | TRPV4MAPTLMNATP53PLTP | |
| SCHEMBL1008694 | 0.88 | TRPV4 (0.36) | TRPV4MAPTLMNATP53PLTP | |
| SCHEMBL6701378 | 0.88 | PPM1D (0.36) | TRPV4MAPTTP53PDE4BPLTP | |
| SCHEMBL7688594 | 0.87 | TRPV4 (0.34) | TRPV4MAPTLMNATP53PLTP | |
| Water SCHEMBL7685985 | 0.86 | TRPV4 (0.33) | TRPV4MAPTLMNATP53PLTP | |
| SCHEMBL6703576 | 0.86 | MAPT (0.36) | TRPV4MAPTTP53PLTPSMN1; SMN2 | |
| SCHEMBL27581687 | 0.85 | PPM1D (0.36) | TRPV4MAPTPLTPSMN1; SMN2 | |
| Diethylamine SCHEMBL7031731 | 0.85 | TRPV4 (0.34) | TRPV4MAPTLMNATP53PLTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345897-A1 | CHEMICAL PROCESS AND NEW INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002044150-A1 | CHEMICAL PROCESS AND NEW INTERMEDIATES | SANOFI-SYNTHELABO (FR) | 2002-06-06 | — | — | WO | disclosed |