Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090261 | 0.91 | KDM4E (0.47) | TRPM8ALOX5EPHX1NR1I2CYP2D6 | |
| SCHEMBL7093905 | 0.89 | EPHX1 (0.47) | TRPM8ALOX5EPHX1NR1I2LMNA | |
| SCHEMBL7094118 | 0.87 | TRPM8 (0.43) | TRPM8NR1I2 | |
| SCHEMBL7092758 | 0.85 | TRPM8 (0.41) | TRPM8EPHX1NR1I2SMN1; SMN2 | |
| SCHEMBL7093888 | 0.84 | CPN1 (0.46) | TRPM8ALOX5EPHX1NR1I2 | |
| SCHEMBL7093895 | 0.83 | IDO1 (0.44) | TRPM8EPHX1NR1I2SMN1; SMN2 | |
| SCHEMBL28275848 | 0.83 | SRC (0.50) | TRPM8ALOX5NPSR1CYP2D6SRC | |
| SCHEMBL7094981 | 0.81 | NR3C2 (0.56) | TRPM8LMNASMN1; SMN2 | |
| SCHEMBL4566801 | 0.80 | TRPM8 (0.53) | TRPM8ALOX5EPHX1NR1I2LMNA | |
| SCHEMBL4152158 | 0.79 | TRPM8 (0.56) | TRPM8ALOX5EPHX1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | claimed |
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | disclosed |