Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 15/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093909 | 0.80 | TRPM8 (0.51) | TRPM8NR1I2ALOX5LMNASMN1; SMN2 | |
| SCHEMBL8802828 | 0.79 | ALDH1A1 (0.46) | TRPM8ALOX5LMNAALDH1A1TP53 | |
| SCHEMBL10974191 | 0.77 | TRPM8 (0.50) | TRPM8NR1I2ALOX5EPHX1 | |
| SCHEMBL28133348 | 0.77 | CES2 (0.45) | ALOX5LMNAALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL18867910 | 0.77 | LMNA (0.51) | TRPM8ALOX5LMNAALDH1A1TP53 | |
| SCHEMBL4152158 | 0.76 | TRPM8 (0.56) | TRPM8NR1I2ALOX5ALDH1A1EPHX1 | |
| SCHEMBL5801209 | 0.76 | TRPM8 (0.47) | TRPM8NR1I2ALOX5ALDH1A1SMN1; SMN2 | |
| SCHEMBL7560686 | 0.75 | ALOX5 (0.44) | TRPM8NR1I2ALOX5LMNAALDH1A1 | |
| SCHEMBL6358138 | 0.74 | TRPM8 (0.51) | TRPM8NR1I2ALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL7757903 | 0.74 | TRPM8 (0.54) | TRPM8NR1I2ALOX5ALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9096565-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2015-08-04 | — | — | US | disclosed |
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. (CA) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181943-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC11, HDAC3 | TRPM8 4155/4885NR1I2 291/4885ALOX5 2866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.