Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | GPR4 | P46093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092953 | 0.81 | EHMT2 (0.56) | EHMT2 | |
| SCHEMBL8306947 | 0.80 | MAPK1 (0.45) | ALDH1A1CYP2C9ALOX15CYP2C19TLR9 | |
| SCHEMBL7097649 | 0.80 | EHMT2 (0.55) | EHMT2 | |
| SCHEMBL7094017 | 0.78 | SYK (0.52) | ALDH1A1EHMT2GAATSHRMAPK1 | |
| SCHEMBL7005111 | 0.76 | DRD3 (0.48) | RXFP1ALDH1A1EHMT2NSD2CFTR | |
| SCHEMBL7011905 | 0.73 | ALDH1A1 (0.53) | RXFP1ALDH1A1MAPTDRD3DRD2 | |
| SCHEMBL19479118 | 0.72 | DRD3 (0.70) | ALDH1A1DRD3DRD2 | |
| SCHEMBL1667304 | 0.71 | NSD2 (0.49) | ALDH1A1EHMT2NSD2TLR9TLR7 | |
| SCHEMBL3196231 | 0.71 | DRD3 (0.50) | RXFP1ALDH1A1TLR9TLR7DRD3 | |
| SCHEMBL25221277 | 0.71 | ALDH1A1 (0.52) | ALDH1A1CYP2C9ALOX15CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |