Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095589 | 0.80 | MEN1 (0.52) | ALOX5KDM4ETDP1POLBKMT2A | |
| SCHEMBL8005769 | 0.77 | DRD3 (0.38) | KDM4ETDP1HTR1AKMT2AMEN1 | |
| SCHEMBL7096822 | 0.70 | HTT (0.45) | KDM4EPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27731418 | 0.69 | LTA4H (0.52) | KDM4EKMT2AMEN1KCNA5ALDH1A1 | |
| SCHEMBL9015951 | 0.69 | MEN1 (0.55) | KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL9015990 | 0.69 | HTT (0.44) | ALOX5KDM4ETDP1POLBKMT2A | |
| SCHEMBL9053303 | 0.69 | HTT (0.44) | ALOX5KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL688109 | 0.68 | THRA (0.46) | ALOX5POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL27998224 | 0.66 | ALDH1A1 (0.37) | POLBKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL27997972 | 0.66 | PAOX (0.40) | KDM4ETDP1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901469-B1 | ARYLALKYLPIPERAZINE COMPOUNDS AS ANTIOXIDANTS | UNIV MONASH (AU) | 2003-08-27 | — | — | EP | disclosed |
| US-6232314-B1 | SUCH AS 1-(2-(4-CHLOROPHENYL)-2-HYDROXY)ETHYL-4-(3,5-BIS(1,1-DIMETHYLETHYL)-4 -HYDROXYPHENYL)METHYLPIPERAZINE; USED TO TREAT STROKE, CARDIAC ARREST, ISCHAEMIA, HYPOXIA, HYPOGLYCAEMIA, EPILEPSY, AND AMYOTROPHIC LATERAL SCLEROSIS | MONASH UNIVERSITY (AU) | 2001-05-15 | — | — | US | disclosed |