Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097655 | 0.86 | NFE2L2 (0.44) | NFE2L2L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL7150847 | 0.83 | NFE2L2 (0.39) | NFE2L2CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL1515778 | 0.76 | CHRM2 (0.48) | CHRM2CHRM1CHRM3L3MBTL1CASR | |
| SCHEMBL6503892 | 0.74 | ROCK2 (0.47) | NFE2L2CHRM2CHRM1CHRM3ROCK2 | |
| SCHEMBL1515839 | 0.72 | KCNA5 (0.47) | NFE2L2CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL1515892 | 0.71 | NFE2L2 (0.49) | NFE2L2CHRM2CHRM1CHRM3SMN1; SMN2 | |
| SCHEMBL7450991 | 0.71 | CHRM2 (0.47) | CHRM2CHRM1CHRM3L3MBTL1MEN1 | |
| SCHEMBL27894882 | 0.71 | CHRM2 (0.49) | CHRM2CHRM1CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL2558825 | 0.71 | CHRM2 (0.51) | CHRM2CHRM1CHRM3SMN1; SMN2L3MBTL1 | |
| SCHEMBL7506748 | 0.70 | GRM5 (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366048-A2 | PYRAZOLOPYRIDINE DERIVATIVES | SmithKline Beecham Corporation (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002072581-A2 | PYRAZOLOPYRIADINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |