Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094473 | 0.86 | NFE2L2 (0.43) | NFE2L2L3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7506748 | 0.84 | GRM5 (0.42) | ALDH1A1MAPK1TDP1TSHRKDM4E | |
| SCHEMBL7141858 | 0.82 | NFE2L2 (0.39) | NFE2L2L3MBTL1ALDH1A1GAALMNA | |
| SCHEMBL6508623 | 0.77 | AHR (0.48) | L3MBTL1ALDH1A1LMNATSHRKDM4E | |
| SCHEMBL4775938 | 0.76 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1MAPK1TDP1TSHR | |
| SCHEMBL7456881 | 0.75 | HPGD (0.50) | NFE2L2L3MBTL1ALDH1A1GAALMNA | |
| SCHEMBL10954259 | 0.74 | NFE2L2 (0.43) | NFE2L2L3MBTL1ALDH1A1GAALMNA | |
| SCHEMBL1515694 | 0.73 | ACP3 (0.56) | L3MBTL1ALDH1A1GAALMNAKMT2A | |
| SCHEMBL4748432 | 0.72 | CYP1A2 (0.40) | NFE2L2L3MBTL1ALDH1A1LMNAMAPK1 | |
| SCHEMBL5319843 | 0.70 | CYP17A1 (0.53) | NFE2L2L3MBTL1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366048-A2 | PYRAZOLOPYRIDINE DERIVATIVES | SmithKline Beecham Corporation (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002072581-A2 | PYRAZOLOPYRIADINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |