Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141858 | 0.87 | NFE2L2 (0.39) | NFE2L2L3MBTL1KDM4EKMT2AMAPT | |
| SCHEMBL7094473 | 0.83 | NFE2L2 (0.43) | NFE2L2AOC3L3MBTL1KMT2ACHRM2 | |
| SCHEMBL7097655 | 0.69 | NFE2L2 (0.44) | NFE2L2L3MBTL1KDM4EKMT2AMAPT | |
| SCHEMBL11619720 | 0.64 | CASR (0.53) | AOC3L3MBTL1CASR | |
| SCHEMBL10954259 | 0.64 | NFE2L2 (0.43) | NFE2L2L3MBTL1KDM4EKMT2AMAPT | |
| SCHEMBL11353744 | 0.64 | AOC3 (0.45) | AOC3L3MBTL1CHRM2CHRM1CHRM3 | |
| SCHEMBL28031817 | 0.63 | AOC3 (0.56) | AOC3L3MBTL1CHRM2CHRM1CHRM3 | |
| SCHEMBL17858535 | 0.63 | DYRK1A (0.42) | NFE2L2CASRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2087869 | 0.63 | AOC3 (0.59) | AOC3L3MBTL1CHRM2CHRM1CHRM3 | |
| SCHEMBL2093768 | 0.63 | AOC3 (0.59) | AOC3L3MBTL1CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1366048-A2 | PYRAZOLOPYRIDINE DERIVATIVES | SmithKline Beecham Corporation (US) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002072581-A2 | PYRAZOLOPYRIADINE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-09-19 | — | — | WO | disclosed |