Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097649 | 0.84 | EHMT2 (0.55) | HRH3EHMT2 | |
| SCHEMBL7096511 | 0.82 | HRH3 (0.54) | HRH3SMN1; SMN2EHMT2MEN1KMT2A | |
| SCHEMBL7094592 | 0.82 | HRH3 (0.54) | HRH3SMN1; SMN2EHMT2MEN1KMT2A | |
| SCHEMBL7092953 | 0.82 | EHMT2 (0.56) | HRH3EHMT2 | |
| SCHEMBL7094945 | 0.80 | HRH3 (0.51) | HRH3SMN1; SMN2EHMT2KDM4EHRH1 | |
| SCHEMBL7094490 | 0.80 | HRH3 (0.51) | HRH3SMN1; SMN2EHMT2TRPM2PARP1 | |
| SCHEMBL8615260 | 0.77 | NOS3 (0.39) | HRH3SMN1; SMN2TDP1PARP1KDM4E | |
| SCHEMBL7094573 | 0.74 | HRH3 (0.77) | HRH3HRH1 | |
| SCHEMBL7092448 | 0.73 | HRH3 (0.52) | HRH3HRH1 | |
| Hydrochloric Acid SCHEMBL6109241 | 0.73 | HRH3 (0.85) | HRH3KMT2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |