Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094551 | 0.89 | NR3C1 (0.56) | NR3C2KEAP1NR3C1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7093212 | 0.88 | NR3C1 (0.54) | NR3C2KEAP1NR3C1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7093914 | 0.78 | TAAR1 (0.52) | CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL7094981 | 0.77 | NR3C2 (0.56) | NR3C2KEAP1PGRSMN1; SMN2NPC1 | |
| SCHEMBL7090263 | 0.74 | CYP3A4 (0.50) | KDM4EALDH1A1HTTMAPTCYP1A2 | |
| SCHEMBL9479877 | 0.74 | NR3C2 (1.00) | NR3C2KEAP1PGRNR3C1HPGD | |
| SCHEMBL7093907 | 0.72 | HTR2A (0.56) | ALDH1A1HTT | |
| SCHEMBL7094120 | 0.71 | SLC6A2 (0.41) | KDM4ELMNAMAPTCASP1 | |
| SCHEMBL23960478 | 0.71 | KEAP1 (0.64) | NR3C2KEAP1PGRHPGDSMN1; SMN2 | |
| SCHEMBL9479898 | 0.69 | KEAP1 (0.83) | NR3C2KEAP1PGRHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | claimed |
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | disclosed |