Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093212 | 0.96 | NR3C1 (0.54) | NR3C1NR3C2HTR7KEAP1ALDH1A1 | |
| SCHEMBL7094983 | 0.89 | NR3C2 (0.57) | NR3C1NR3C2KEAP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7094549 | 0.78 | NR3C1 (0.52) | NR3C1NR3C2HTR7KEAP1ALDH1A1 | |
| SCHEMBL7093211 | 0.76 | NR3C1 (0.50) | NR3C1NR3C2HTR7KEAP1ALDH1A1 | |
| SCHEMBL7093914 | 0.76 | TAAR1 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL7094120 | 0.75 | SLC6A2 (0.41) | CYP3A4 | |
| SCHEMBL11420225 | 0.75 | ADRB3 (0.61) | KEAP1ALDH1A1ADRA2CADRA1AADRA1B | |
| SCHEMBL9481726 | 0.74 | NR3C2 (0.78) | NR3C1NR3C2HTR7KEAP1ALDH1A1 | |
| SCHEMBL11570895 | 0.74 | ALDH1A1 (0.50) | NR3C1KEAP1ALDH1A1ADRA2CADRA1A | |
| SCHEMBL4370199 | 0.74 | KEAP1 (0.52) | NR3C1KEAP1ALDH1A1SMN1; SMN2MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | claimed |
| WO-2003082777-A2 | NOVEL GLUCOCORTICOID RECEPTOR LIGANDS | KARO BIO AB (SE) | 2003-10-09 | — | — | WO | disclosed |