Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6908528 | 0.87 | MMP8 (0.64) | MMP8MEN1KMT2ANPC1CA12 | |
| SCHEMBL6622793 | 0.86 | MAPT (0.40) | MMP8MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6623057 | 0.86 | MAPT (0.40) | MMP8MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8200333 | 0.85 | MMP8 (0.55) | MMP8MEN1KMT2ANPC1CA12 | |
| SCHEMBL7093633 | 0.83 | MMP8 (0.52) | MMP8MEN1KMT2ANPC1CA12 | |
| SCHEMBL7093345 | 0.82 | NPC1 (0.56) | MMP8MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL27324944 | 0.81 | MMP8 (0.50) | MMP8MEN1KMT2ANPC1CA12 | |
| SCHEMBL7092555 | 0.80 | MMP8 (0.59) | MMP8MEN1KMT2ANPC1CA12 | |
| SCHEMBL7925167 | 0.78 | MMP8 (0.47) | MMP8MEN1KMT2ANPC1AKR1C3 | |
| SCHEMBL13228057 | 0.77 | MMP8 (0.47) | MMP8MEN1KMT2ANPC1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003084935-A2 | DIARYL PYRIMIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF INFLAMMATION AND IMMUNOGOLICAL DISEASES | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-10-16 | — | — | WO | disclosed |