Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576321 | 0.92 | IDO1 (0.50) | IDO1TDO2KMT2ACYP3A4MAPT | |
| SCHEMBL383767 | 0.79 | MEN1 (0.57) | IDO1TDO2KMT2ACYP3A4MAPT | |
| SCHEMBL4784600 | 0.71 | IDO1 (0.57) | IDO1TDO2HPGDCES1RAB9A | |
| SCHEMBL10664130 | 0.68 | KMT2A (0.57) | KMT2ACYP3A4MAPTMEN1HPGD | |
| SCHEMBL2394174 | 0.67 | DPEP1 (0.49) | TDP1NPC1RAB9AMAOAMAOB | |
| SCHEMBL1907796 | 0.67 | DPEP1 (0.49) | TDP1NPC1RAB9AMAOAMAOB | |
| SCHEMBL24181250 | 0.67 | VCP (0.46) | IDO1TDO2TDP1NPC1RAB9A | |
| Dibenzoylmethane SCHEMBL10356288 | 0.66 | MEN1 (1.00) | KMT2ACYP3A4MAPTMEN1HPGD | |
| Dibenzoylmethane SCHEMBL1704711 | 0.66 | MEN1 (1.00) | KMT2ACYP3A4MAPTMEN1HPGD | |
| Dibenzoylmethane SCHEMBL39582 | 0.66 | MEN1 (1.00) | KMT2ACYP3A4MAPTMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307453-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010164-A2 | DIHYDRONAPHTHYRIDINE- AND DIHYDROPYRROLOPYRIDINE-DERIVATED COMPOUNDS AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-02-07 | — | — | WO | disclosed |