Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100614 | 0.92 | MMP8 (0.37) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7099916 | 0.89 | MMP8 (0.39) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7100102 | 0.80 | ADAM17 (0.41) | GAAMMP8ANPEPADAM17MMP1 | |
| SCHEMBL7100104 | 0.79 | ANPEP (0.37) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7101371 | 0.75 | MMP8 (0.35) | MMP8ANPEPMMP1MMP2FCER2 | |
| SCHEMBL7101854 | 0.74 | ADAM17 (0.33) | ADAM17MMP1MMP2KDM4ELMNA | |
| SCHEMBL7102058 | 0.74 | ADAM17 (0.36) | ADAM17 | |
| SCHEMBL6942520 | 0.74 | ADAM17 (0.41) | MMP8ADAM17MMP1MMP2MMP9 | |
| SCHEMBL7102324 | 0.72 | MMP8 (0.34) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL6982649 | 0.72 | ANPEP (0.40) | MMP8ANPEPADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |