Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.35 |
| ▸ | MMP1 | P03956 | 5/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | FCER2 | P06734 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100635 | 0.92 | GAA (0.37) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7099916 | 0.91 | MMP8 (0.39) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7100104 | 0.80 | ANPEP (0.37) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7101371 | 0.76 | MMP8 (0.35) | MMP8ANPEPMMP1MMP2MMP9 | |
| SCHEMBL6942520 | 0.75 | ADAM17 (0.41) | MMP8ADAM17MMP1MMP2MMP9 | |
| SCHEMBL7106109 | 0.74 | CTSB (0.35) | ADAM17CA1 | |
| SCHEMBL7104740 | 0.74 | ADAM17 (0.34) | MMP8ADAM17MMP1MMP2MMP9 | |
| SCHEMBL7102324 | 0.74 | MMP8 (0.34) | MMP8ANPEPADAM17MMP1MMP2 | |
| SCHEMBL7104768 | 0.74 | ADAM17 (0.37) | ADAM17MMP1 | |
| SCHEMBL6982649 | 0.74 | ANPEP (0.40) | MMP8ANPEPADAM17MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |